None
Conditions
Interventions
Experimental group:30% air-oxygen mixture
Control group:60% air-oxygen mixture
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age< 18 years old; 2. Planned elective non-thoracic surgery, requiring mechanical ventilation for more than 2 hours after general anesthesia intubation; 3. Have an American Society of Anesthesiologists (ASA) physical status class I to III.
Exclusion criteria
Exclusion criteria: 1. Planned laparotomy combined with intrathoracic surgery, or prone or lateral surgery; 2. Body mass index (BMI) more than 35kg/m^2; 3. History of pneumothorax, acute lung injury, or acute respiratory distress syndrome within the past 3 months; 4. Serious illness, including severe chronic obstructive pulmonary disease (COPD) (GOLD III or IV or home (non-invasive) ventilation and/or oxygen therapy), severe heart disease (New York Heart Association will be class III or IV), severe liver disease (eg, liver failure), chronic renal failure (renal failure (glomerular filtration rate< 30 mL min-1 1.73 m^2); 5. Chest imaging shows pneumothorax or megapulmonary blisters; 6. Mechanical circulatory support or reoperation is required after surgery; 7. Patients participating in any other clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atelectasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory tract infection;Aspiration pneumonia;Postoperative fever ( body temperature =37.5°C);The incidence of postoperative hypoxemia (SpO2 < 94%);Bronchospasm;Pleural effusion;Respiratory failure; | — |
Countries
China
Contacts
Public ContactShao Huiying
Children's Hospital of Fudan University
Outcome results
None listed