Coronary heart disease
Conditions
Interventions
Control group:The patient was given a saline nasal spray 1 hour before entering the operating room
Experimental group:The patient was given dexmedetomidine nasal spray 1 hour before admission to the operating room
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. A total of 70 patients aged 18–80 years who were planned to undergo elective CABG 2. ASA LEVEL II–III 3. Cardiac function NYHA class I–III 4. Clear awareness, able to correctly understand and cooperate with questionnaires and rating scales 5. Signed informed consent and voluntarily participated in the study
Exclusion criteria
Exclusion criteria: 1. Those who have a history of allergy to dexmedetomidine or its excipients 2. Those with obvious nasal anatomical abnormalities or chronic nasal diseases (such as severe deviated septum, nasal polyps, sinusitis, persistent nasal congestion, etc.) that affect drug absorption 3. Severe hepatic and renal insufficiency (eg, Child-Pugh class C, eGFR<30 ml/min) 4. Combined with severe arrhythmias, such as II-III degree atrioventricular block, sick sinus node syndrome 5. Those who carry pacemakers 6. Mental disorders, dementia, language expression disorders or cognitive dysfunction, unable to accurately cooperate with the raters 7. Those who have used central nervous system sedatives (such as benzodiazepines, antipsychotics) in the previous 2 weeks 8. Pregnant or lactating women 9. Those who have adverse reactions or request to withdraw during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Norepinephrine concentration;The patient's preoperative anxiety level; | — |
Countries
China
Contacts
Public ContactLuan Yong
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed