Postoperative delirium
Conditions
Interventions
Experimental Group: Esketamine 0.5 mg/kg Group (Group E0.5):Esketamine 0.5 mg/kg
Experimental Group: Esketamine 0.15 mg/kg Group (Group E0.15):Esketamine 0.15 mg/kg
Experimental Group: Esketamine 0.25 mg/kg Group (Group E0.25):Esketamine 0.25 mg/kg
Control group: Placebo group:Placebo
Sponsors
The Central Hospital of Wuhan
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1: Aged 60-80 years. 2: Diagnosed with gastrointestinal malignant tumor based on imaging and pathological examinations, and assessed as meeting surgical indications. 3: Scheduled to undergo their first laparoscopic gastrointestinal tumor surgery. 4: American Society of Anesthesiologists (ASA) physical status classification II-III. 5: Amsterdam Preoperative Anxiety and Information Scale (APAIS) score >= 12.
Exclusion criteria
Exclusion criteria: 1: Preoperative Montreal Cognitive Assessment (MoCA) score = 28 kg/m^2. 7: Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure exceeding 180/100 mmHg). 8: Patients with psychiatric disorders; or those regularly using sedatives, antidepressants, or other drugs affecting metabolism. 9: Patients with sinus bradycardia or severe atrioventricular block. 10: Patients with untreated or poorly controlled hyperthyroidism. 11: Patients with acute angle-closure glaucoma. 12: Patients allergic to the active ingredient or any excipient of esketamine. 13: Patients with hepatic insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium;postoperative cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety;Hemodynamic adverse events;Intraoperative vital signs;postoperation pain;The dosage of propofol and remifentanil during the operation;emergence agitation;The concentrations of serum interleukin-6 (IL-6), central nervous system specific protein (S100ß), and neuron-specific enolase (NSE); | — |
Countries
China
Contacts
Public ContactJin Zha
The Central Hospital of Wuhan
Outcome results
None listed