Kidney Diseases
Conditions
Interventions
Vitamin C:20 mg/kg vitamin C + 100 ml 0.9% NaCI
Control:No additional intervention
Sponsors
Xijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Obtained written informed consent; 2. Aged 18 to 80 years; 3. Scheduled to undergo percutaneQus ultrasound-guided native kidney biopsy
Exclusion criteria
Exclusion criteria: 1. Allergy or hypersensitivity to any component of the vitamin C injection or a history of allergic predisposition; 2. Significant bleeding tendency, defined as any of the following: (1) Recent use of anticoagulant or antiplatelet medications: - Anticoagulants: Discontinuation of warfarin 13.5 s,APTT 53.6 s,or TT 22.2 s; 3. Uncontrolled severe hypertension, defined as preoperative systolic blood pressure >180 mmHg despite antihypertensive therapy; 4. High-risk renal anatomy, including: - Atrophic kidney (length <8 cm) - Solitary kidney - Polycystic kidney disease - Floating kidney (inability to stabilize kidney position during biopsy) - Abnormally high kidney position 5. Severe comorbidities or poor general condition, including: - Renal tumor - Severe heart failure (NYHA class III-IV) - Severe thrombocytopenia (<80×10^9/L) - Severe anemia (hemoglobin <60 g/L) 6. Inability to maintain prone positioning due to massive ascites/pleural effusion, morbid obesity, or respiratory conditions; 7. Pregnancy or lactation; 8. Oliguria (24-hour urine output <400 mL); 9. Hematologic or metabolic disorders affecting coagulation, including: - Thalassemia - Cystinuria - Glucose-6-phosphate dehydrogenase (G6PD) deficiency - Other coagulopathies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perirenal hematoma;Postoperative pain score;AE incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of early hemorrhagic complications;Pain incidence; | — |
Countries
China
Contacts
Public ContactLijie He
Xijing Hospital, the First Affiliated Hospital of the AirForce Medical University
Outcome results
None listed