Deep Venous Insufficiency
Conditions
Interventions
DVI:Clinical assessment, imaging examination, and functional parameter collection.
Control:Clinical assessment, imaging examination, and functional parameter collection.
Sponsors
Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Patients: 1. Aged between 18 and 75 years, with normal function of major organs; 2. Classified as any clinical category C0 to C6 according to the CEAP classification, and diagnosed with primary venous insufficiency; 3. Diagnosed with chronic venous disease of the lower limbs by color Doppler ultrasound and venography. Inclusion Criteria for Healthy Controls: 1. Aged between 18 and 75 years, with normal function of major organs; 2. No subjective symptoms such as heaviness or soreness in the lower limbs; 3. No clinical signs of varicose veins, skin pigmentation, or ulcers in the lower limbs; 4. Color Doppler ultrasound examination of the lower limb veins (including deep, superficial, and perforating veins) shows no abnormalities in patency or reflux.
Exclusion criteria
Exclusion criteria: 1. Individuals with venous obstruction or post-thrombotic syndrome (PTS); 2. Individuals with a history of lower limb venous surgery; 3. Individuals with concomitant peripheral arterial disease (defined as an ankle-brachial index < 0.9); 4. Individuals with a history of systemic diseases such as angina, myocardial infarction, asthma, chronic obstructive pulmonary disease (COPD), chronic heart failure, liver failure, renal failure, or malignancy; 5. Individuals who are pregnant or planning to become pregnant; 6. Individuals with a history of musculoskeletal degenerative diseases; 7. Individuals unable to tolerate intravenous cannulation or unable to follow instructions to complete physical movements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| venous structural and functional parameters;hemodynamic parameters;proteomic indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| medical history and demographic characteristics;lifestyle and exposure history; | — |
Countries
China
Contacts
Public ContactYifei Hu
China Capital Medical University
Outcome results
None listed