Postoperative delirium
Conditions
Interventions
Normal Saline Group:Subcutaneous injection of normal saline
Liraglutide Group:Subcutaneous injection of liraglutide. 0.6 mg on the day before surgery, 1.8 mg after anesthesia induction on the day of surgery, and 0.6 mg daily for postoperative days 1 to 3.
Sponsors
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 60 years; 2.Patients undergoing elective cardiac surgery;
Exclusion criteria
Exclusion criteria: 1.History of neurological or psychiatric disorders, such as schizophrenia, epilepsy, Parkinson's disease, severe dementia, etc; 2.Patients with communication difficulties, such as severe visual, auditory, or speech impairments; 3.History of central nervous system damage or surgery; 4.Cardiac function NYHA Class IV; 5.Severe liver dysfunction (Child-Pugh Class C); 6.Severe renal failure requiring renal replacement therapy; 7.History of pancreatitis; 8.Type 1 diabetes; 9.Patients whose blood glucose cannot be controlled within 4–10 mmol/L during the screening period. 10.Patients with medullary thyroid carcinoma or a family history of it; 11.Pregnant or breastfeeding women; 12.Intolerance or allergy to liraglutide; 13.Previous use of GLP-1As; 14.Patients who refuse to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium within 7 days postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac function;Cognitive function, anxiety, depression, post-traumatic stress disorder, sleep, and cardiac function.;Neurological injury markers (NSE), inflammatory markers (CRP, IL-6), myocardial injury markers (cTnT, LDH, AST, CK, CK-MB), and cardiac function marker (BNP).;The incidence of delirium within 7 days postoperatively;Incidence of adverse events during medication use;Rate of major cardiovascular adverse events (including cardiovascular death, myocardial infarction, stroke);ICU length of stay, duration of mechanical ventilation, total hospital stay, and in-hospital mortality.; | — |
Countries
China
Contacts
Public ContactLiu Wenxue
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Outcome results
None listed