Depth of anesthesia
Conditions
Interventions
Dixon Sequential Test Group:Continuous intravenous pumping of magnesium sulfate loading dose of 30 mg/kg over 15 minutes before induction of anesthesia
Sponsors
Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: -Age range 18-65 years. -ASA classification I-II. -Proposed elective surgery under general anesthesia; -BMI 18.5 - 28kg/m^2; -No abnormal preoperative serum magnesium.
Exclusion criteria
Exclusion criteria: -Patient refusal to participate; -perennial alcohol addiction, long-term use of drugs affecting mental status (e.g., sedatives) and monoamine oxidase inhibitors; -combined psychiatric and psychological disorders resulting in impaired cognitive function; -Comorbidities with severe hepatic dysfunction (e.g., Child-Pugh class C) or abnormal renal function (e.g., preoperative dialysis); -Patients with hypersensitivity to perioperative use of drugs (especially benzodiazepines); -Patients with neuromuscular diseases; -Persons who have been using magnesium preparations for a long period of time; -Pregnant or lactating women; -Patients with poorly controlled hypertension (SBP > 180 mmHg); -Patients with a history of stroke; -Arrhythmias, preoperative left ventricular ejection fraction less than 30%, sick sinus node syndrome, severe sinus bradycardia (< 50 beats/minute or atrioventricular block of degree II and above with pacemaker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dosage of remazolam during intravenous induction to loss of consciousness when compounded with magnesium sulfate agent; | — |
Countries
China
Contacts
Public ContactLongfei Wang
Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University
Outcome results
None listed