Large vessel occlusion acute ischemic stroke,AIS-LVO.
Conditions
Interventions
Test group:Continuous arterial heparin was administered by a high-pressure infusion
Control group:Conventional heparin
Sponsors
Chongqing Emergency Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with AIS due to proximal cerebral artery occlusion were enrolled for mechanical thrombectomy according to the following criteria: 1. Age >=18 years, initial National Institutes of Health Stroke Scale (NIHSS) score >=5; 2. index pre-stroke modified Rankin scale (mRS)<=2; 3 When the clinical symptoms were severe, the proximal cerebral artery occlusion was confirmed by imaging examination, including intracranial internal carotid artery (ICA), M1/M2 segment of middle cerebral artery (MCA), basilar artery (BA) occlusion or dominant vertebral artery (VA) occlusion (functional vertebral artery occlusion), and tandem extracranial ICA and intracranial large artery occlusion were also included. 4. Eligible patients with acute large vessel occlusion undergoing MT, patients beyond the time window (6-24h) met the Dawn and defuse3 criteria. 5. For patients within 4.5 hours after stroke onset, intravenous thrombolysis (IVT) was performed when MT (direct bridging IVT therapy) was prepared according to current guidelines. If IVT was contraindicated or refused, MT was performed directly. 6. Informed consent was obtained from the subjects or their legally authorized representatives. 7.The onset-to-puncture (OTP) time for anterior circulation stroke (ACS) is less than 12 hours, while for posterior circulation stroke (PCS), it is less than 24 hours.
Exclusion criteria
Exclusion criteria: 1. NIHSS score <=5; 2. mass effect with significant midline shift on CT or MRI scan; 3. It was not possible to follow up for 90 days; 4. patients with arterial thrombolysis alone and those who could not undergo MT for any other reason; 5. Patients with contraindications to heparin use; 6. The investigators considered that they were not suitable for participating in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcomes of stroke;Symptomatic intracranial hemorrhage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Any intracerebral hemorrhage (ICH) or midline shift (MT) noted on the follow-up CT or MRI images, as well as any distal embolism during the period.;The mortality rate(mRS = 6) and the poor 3-month follow-up outcome (mRS 3-5) ; | — |
Countries
China
Contacts
Public ContactMeng Tao
Chongqing Emergency Medical Center
Outcome results
None listed