Patients undergoing general anesthesia with sufentanil-induced tracheal intubation
Conditions
Interventions
Group O0:5 ml of 0.9% normal saline
Group O1:0.4mg of oxybutynin is prepared into 5ml.
Group O2:0.5mg of oxybutynin is prepared into 5ml.
Group O3:0.6mg of oxybutynin is prepared into 5ml.
Group O4:0.7mg of oxybutynin is prepared into 5ml.
Group O5:0.8mg of oxybutynin is prepared into 5ml.
Sponsors
The First People's Hospital of Tianshui
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged over 18 years old with ASA grade 1-3 who need general anesthesia with tracheal intubation.
Exclusion criteria
Exclusion criteria: Patients with allergies, sinus bradycardia, severe neurological, respiratory or cardiovascular diseases, dependence on anesthetic drugs and a recent history of opioid use, smoking history, liver or kidney dysfunction, pregnancy, lactation and delivery surgeries, or upper respiratory tract infections within 2 weeks after surgery may experience spontaneous choking cough.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of choking cough after fentanyl injection after pretreatment with different doses of oxilizine; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of people experiencing varying degrees of choking cough after being pre-treated with different doses of oxythiopaine;Systolic blood pressure;Diastolic blood pressure;Heart rate;Minimum pulse oxygen saturation;Other side effects related to oxilezine and sufentanil (rigidity of the trunk and low oxygen saturation (SpO? < 90%), nausea and vomiting); | — |
Countries
China
Contacts
Public ContactLi Chenguang
The First People's Hospital of Tianshui
Outcome results
None listed