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Optimization of the dose of oxycodone hydrochloride and butorphanol tartrate for postoperative analgesia: analysis of dose-response relationship based on opioid receptor synergy

Optimization of the dose of oxycodone hydrochloride and butorphanol tartrate for postoperative analgesia: analysis of dose-response relationship based on opioid receptor synergy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500106910
Enrollment
Unknown
Registered
2025-07-31
Start date
2025-08-04
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients requiring total hysterectomy under laparoscopy

Interventions

Q1:Q1 group transition analgesia used 5mg oxycodone hydrochloride injection
Q2:Q2 group transition analgesia using 3mg oxycodone injection + 0.4mg butorphanol tartrate injection
Q3:Q3 group transition analgesia using 1mg oxycodone injection + 0.8mg butorphanol tartrate injection
Q4:Q4 group transition analgesia using 1mg/butorphanol tartrate injection

Sponsors

Benxi Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
35 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Female, age 35-65 years; 2. BMI 18-28kg/m²; 3. Patients who plan to undergo laparoscopic surgery under general anesthesia with ASA grade I or II; 4. Patients who plan to receive postoperative analgesia; 5. Sign the anesthesia informed consent form; 6. Good mental state and able to cooperate with postoperative investigation;

Exclusion criteria

Exclusion criteria: 1. Patients with severe cardiovascular or respiratory diseases; 2. Those with severe hypertension, diabetes, or atherosclerosis; 3. Individuals with pre-existing chronic pain prior to surgery; 4. Patients with a history of drug abuse or prolonged opioid use; 5. Patients with severe mental disorders or those requiring long-term antipsychotic medication; 6. Patients experiencing intraoperative blood loss = 400ml

Design outcomes

Primary

MeasureTime frame
Pain;

Secondary

MeasureTime frame
degree of comfort ;sedation ;Dosage of analgesics;Wake up time;untoward effect ;

Countries

China

Contacts

Public ContactWang Shu

Benxi Central Hospital

wang_sugar@163.com+86 189 4143 6099

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026