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A study on a novel Near-Infrared fluorescent molecular probe based on humanized ferritin for identifying benign and malignant sentinel lymph nodes in early gastric cancer

A study on a novel Near-Infrared fluorescent molecular probe based on humanized ferritin for identifying benign and malignant sentinel lymph nodes in early gastric cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500106885
Enrollment
Unknown
Registered
2025-07-31
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric cancer

Interventions

Gold Standard:Histopathological biopsy results
Index test:Fluorescence signals and pathological results were correlated to evaluate the accuracy and efficacy of fluorescent probes in the identification of benign and malignant lymph nodes in sentin

Sponsors

Southern Medical University Southern Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Pathological or cytological diagnosis of gastic cancer or gastroesophageal junction cancer,and radical resection can be performed.and histological examination confirms that it is mainly adenocarcinoma; 2.Age: 18 years old and above; 3.Gender: male and female; 4.Those who voluntarily participate and have informed consent;

Exclusion criteria

Exclusion criteria: 1.Considered unsuitable for study participation based on investigator assessment;

Design outcomes

Primary

MeasureTime frame
The AUC value of the targeted probe VE/CX-FTn-ICG for identifying benign and malignant sentinel lymph nodes;

Secondary

MeasureTime frame
Detection of TfR1 expression in malignant SLN;Distribution of probes in malignant SLN;Mean fluorescence intensity of benign and malignant SLNs;Incidence of all adverse events (AES);

Countries

China

Contacts

Public ContactYanfeng Hu

Southern Medical University Southern Hospital

yfenghu@qq.com+86 13632494551

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026