Lung cancer
Conditions
Interventions
Observation group:None
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Histologically confirmed squamous cell carcinoma or non-squamous cell carcinoma, AJCC 8th edition stage is stage III unresectable or stage IV, non-squamous cell carcinoma NSCLC subjects, no EGFR-sensitive mutation or ALK fusion gene; 2. The subject's PS score is 0-2 points, and he can receive the corresponding immune monotherapy or immune combination drug treatment; 3. Age>=18 years old; 4. Subjects voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Positive baseline pregnancy test test for pregnant, lactating female patients or women of childbearing potential; 2. Lung interstitial disease, drug-related pneumonia or other radiation pneumonitis that still require drug intervention; 3. Subjects cannot tolerate immune monotherapy or immune combination therapy regimens.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mutations in the DNA damage repair (DDR) gene; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor Mutational Burden, TMB;Programmed Death-Ligand 1, PD-L1;Time to Treatment Failure, TTF; | — |
Countries
China
Contacts
Public ContactHan Bin
The First Hospital of Shanxi Medical University
Outcome results
None listed