None
Conditions
Interventions
Fospropofol Group:The initial dose of fospropofol disodium for injection in first patient is 10mg/kg, the dose of the next patient is determined by the response to laryngeal mask insertion of the prev
Sponsors
Beijing Shijingshan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. From 18 years old to 65 years old, regardless of gender; 2. Body mass index (BMI) between 18~30 kg/m^2; 3. ASA classification is I-III level; 4. Patients undergoing elective surgery with laryngeal mask general anesthesia; 5. Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals with contraindications to general anesthesia; 2. Patients with traumatic brain injury, intracranial hypertension, history of cerebrovascular accidents, or central nervous system diseases (such as epilepsy), unstable angina pectoris, myocardial infarction; 3. Patients has obstructive pulmonary disease, respiratory insufficiency, and significant dysfunction of important organs such as the liver and kidneys; 4. History of drug abuse and/or alcohol abuse; 5. Allergy to anesthetic drugs or presence of contraindications; 6. History of mental illness; 7. Disability of communication caused by severe dementia, consciousness disorder, language disorder, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 of fospropofol disodium for injection to inhibit responses to laryngeal mask insertion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;SpO2;Anesthesia onset time;Wake time;Adverse drug reaction; | — |
Countries
China
Contacts
Public ContactJie Geng
Beijing Shijingshan Hospital
Outcome results
None listed