Colorectal Polyps
Conditions
Interventions
ED50 group:The ED50 was determined using Dixon’s up-and-down method. An effective anesthetic response was defined as a Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score = 1 and absen
Oliceridine group:The ED95 of oliceridine determined in the first phase was administered via slow intravenous injection. Simultaneously, propofol was infused using target-controlled infusion (TCI) at
Sufentanil group:According to the literature, the sufentanil dose was calculated based on an equivalent ratio of 200:1 to oliceridine (ED95/200) and administered via slow intravenous injection. Simult
Sponsors
Jurong People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged >=65 years with colorectal polyps scheduled for elective endoscopic mucosal resection (EMR); 2. ASA physical status classification I–III; 3.Clear consciousness before surgery, able to communicate normally, understand the study content, and provide written informed consent; 4. Body Mass Index (BMI) between 18 and 30 kg/m^2; 5. No planned combined surgery, EMR procedure performed as a standalone operation.
Exclusion criteria
Exclusion criteria: 1. Severe dysfunction of the liver, kidneys, heart, or brain (e.g., Child-Pugh class C, eGFR < 30 ml/min, NYHA class IV cardiac function, recent history of stroke, etc.); 2. Known or suspected allergy to oliceridine, propofol, sufentanil, or related drugs; 4. Decompensated respiratory diseases (e.g., severe COPD, untreated moderate-to-severe OSAHS); 5.Active bleeding, coagulopathy, or ongoing anticoagulant therapy that cannot be discontinued prior to surgery; 6.Preoperative psychiatric disorders, cognitive impairment, or altered consciousness; 7. Prior participation in similar clinical studies involving anesthetic agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oliceridine dosage;Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic changes;Waking time;The incidence of postoperative nausea and vomiting;Patient satisfaction;QoR-15; | — |
Countries
China
Contacts
Public ContactLiu Ying
Jurong People's Hospital
Outcome results
None listed