Sepsis
Conditions
Interventions
control group:N/A
Sponsors
Nanjing First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Meet diagnostic criteria: Patients diagnosed with sepsis according to the Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 (jointly issued by the European Society of Intensive Care Medicine, ESICM, and the American Society of Critical Care Medicine, SCCM) and fulfilling the Sepsis-3.0 diagnostic criteria; 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnancy; 2. History of neuropsychiatric disorders or current diagnosis of epilepsy, psychosis, or depression; 3. Post-cardiopulmonary cerebral resuscitation (post-CPCR); 4. HIV infection, central nervous system (CNS) infections, cerebrovascular accidents, or intracranial organic lesions; 5. Mini-Mental State Examination (MMSE) score < 24; 6. Diagnosis of Parkinson’s disease, frontotemporal dementia, Huntington’s disease, demyelinating diseases, post-traumatic dementia, or CNS infections; 7. MRI contraindications (e.g., magnetic/mechanical implants, metallic implants, cochlear implants, etc.); 8. Severe visual/hearing impairment, severe aphasia, or limb dysfunction that may interfere with assessments; 9. Prior organic brain lesions (e.g., cerebral infarction, hemorrhage) confirmed by imaging (head CT and/or MRI); 10. History of alcohol addiction or substance abuse; 11. Impaired consciousness due to other factors; 12. Missing data or loss to follow-up; 13. Autoimmune diseases; 14. Use of medications that may interfere with cognitive function evaluation; 15. Death within <3 days of observation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RNA-seq;Metabolomics sequencing;glymphatic system; | — |
Secondary
| Measure | Time frame |
|---|---|
| peripheral blood biochemical indicators;blood routine examination; | — |
Countries
China
Contacts
Public ContactYuan Zhang
Nanjing First Hospital
Outcome results
None listed