Type A aortic dissection
Conditions
Interventions
Control group:None
Autologous platelet-rich plasmapheresis (APP) group:Autologous platelet-rich plasmapheresis
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old, gender not limited. 2.Undergo open surgery for aortic dissection. 3.Weight >=60kg, hemoglobin>120 g/L, platelet count>=120×10^9/L. 4.Understand the purpose of this trial and voluntarily participate, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Mechanical ventilation assistance is required before the operation. 2.Over 75 years old or under 18 years old. 3.Preoperative cardiogenic shock, cardiac arrest, severe hypotension (maintained with two or more vasoactive drugs), mixed venous oxygen saturation <75%, and mechanical circulatory support. 4.Combined with renal failure, blood purification treatment is required. 5.Combined with severe coagulation dysfunction or obvious bleeding tendency. 6.The known disease history of heparin-induced thrombocytopenia. 7.In a state of pregnancy or lactation. 8.Patients who have been diagnosed with severe mental illness and those who may affect the research results. 9.There are other circumstances that may affect the research results or safety, which shall be excluded by the researcher's judgment. 10.The researchers consider it unsuitable to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Red blood cell transfusion volume during the perioperative period of 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss;Perioperative usage of blood products;Postoperative complications;Drainage volume of intrathoracic drain;Length of stay in intensive care unit;Mortality;Rehospitalization; | — |
Countries
China
Contacts
Public ContactChengliang Zhang
Xiangya Hospital, Central South University
Outcome results
None listed