Hepatitis B virus related acute-on-chronic liver failure
Conditions
Interventions
High-dose intravenous immunoglobulin group (IVIg Group):NA
Standard medical treatment Group (SMT Group):NA
Sponsors
Second Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.We adopt the diagnostic criteria of acute on chronic liver failure (2009 version) issued by the Asian Pacific Association for the study of the liver (APASL), which is more suitable for patients in the Asia Pacific region. The criteria include acute injury of liver function occur on the basis of known or unknown chronic liver diseases, which have jaundice [diagnostic index: total bilirubin (TBIL) = 85 µ mol/l or 5 mg/dl, which must be reached]; and have abnormal coagulation function [diagnostic index: prothrombin time activity (PTA) 5 × 10E2 copies/ml; 4.Cases' ages ranged from 18 to 65 completed years.
Exclusion criteria
Exclusion criteria: 1.Cases with alcoholic liver disease, drug-induced liver disease and cholestatic liver disease will be excluded; 2.Cases with decompensated cirrhosis will be excluded; 3.Cases with autoimmune liver disease or other autoimmune diseases will be excluded; 4.Cases with coinfection of hepatitis A, C, D, E virus or other liver related virus infections will be excluded; 5.Cases with diabetes, pancreatitis or other diseases that seriously affect metabolism will be excluded; 6.Cases with tuberculosis, epilepsy or other diseases which need medicine may causing relatively great liver injury will be excluded; 7.Cases received immunoglobulin, glucocorticoid or anticoagulant drugs within 4 weeks before admission will be excluded; 8.Cases with malignant tumor, cardiorespiratory, renal failure or severe infection of other organs will be excluded;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The score of model for end-stage liver disease (MELD).; | — |
Countries
China
Contacts
Public ContactWeidong Liu
Second Affiliated Hospital of Shantou University Medical College
Outcome results
None listed