Acute Coronary Syndromes with Type 2 Diabetes
Conditions
Interventions
semaglutide treatment group:semaglutide treatment
Sponsors
Hebei General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Males or females aged >=18 and 90°).
Exclusion criteria
Exclusion criteria: (1) Allergy or hypersensitivity to semaglutide. (2) Prior use of GLP-1 receptor agonists (GLP-1RA) before randomization. (3) Liver dysfunction (alanine aminotransferase >3× the upper limit of normal). (4) Renal dysfunction (creatinine clearance <45 mL/min). (5) Thrombocytopenia (platelet count <100 ×10?/L). (6) Uncontrolled infectious diseases. (7) Known immune-related diseases, including systemic lupus erythematosus, asthma, inflammatory bowel disease, gout, or malignancy. (8) Prior or planned systemic anti-inflammatory therapy, such as NSAIDs, corticosteroids, immunomodulators, or chemotherapy. (9) Surgery or interventional procedures within the past 6 months. (10) History of coronary artery bypass grafting (CABG) or planned CABG within 1 year. (11) Left main coronary artery disease (=50% lumen diameter reduction by angiography). (12) Severe coronary calcification or tortuosity deemed unsuitable for OCT assessment. (13) Psychiatric disorders (e.g., anxiety, depression). (14) Pregnancy, lactation, or women of childbearing potential not using effective contraception. (15) Participation in another clinical trial within the past 3 months. (16) Congenital heart disease without standardized treatment. (17) Life expectancy <1 year. (18) Investigator’s judgment of unsuitability for trial participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hsCRP;IL-1;IL-6;IL-18;IL-1ß;MPO;AZU1;Caspase-1CD86;CD206;oxLDL;TNFa;CD62L;MCP-1;ICAM-1; | — |
Countries
China
Contacts
Public ContactDang Yi
Hebei General Hospital
Outcome results
None listed