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Determination of ED90 of Oliceridine combined with Propofol in inhibiting responses to laryngeal mask insertion in Elderly Patients: a biased coin up-and-down design

Determination of the 90% Effective Dose (ED90) of Oliceredine for Laryngeal Mask Airway Insertion in Elderly Patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106822
Enrollment
Unknown
Registered
2025-07-30
Start date
2025-08-06
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Experimental group:Adjust the oliceridine dose one by one

Sponsors

Eye & ENT Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age 60-75 years; 2. American Society of Anesthesiologists (ASA) physical status I or II; 3. Patients undergoing general anesthesia with laryngeal mask airway placement; 4. Body Mass Index (BMI) 18-28 kg/m^2.

Exclusion criteria

Exclusion criteria: 1. Emergency patients with full stomach; 2. Patients with severe cardiac, cerebral, pulmonary, hepatic, or renal diseases; 3. Patients with psychiatric or severe psychological disorders; 4. Patients with known allergy to anesthetic drugs or components; 5. Patients with anticipated difficult airway.

Design outcomes

Primary

MeasureTime frame
The LMA insertion condition;Vital signs;—

Secondary

MeasureTime frame
Success rate of LMA placement;Number of attempts for LMA placement;Respiratory depression score;PONV;Urinary retention;—

Countries

China

Contacts

Public ContactJi'e Jia

Eye & ENT Hospital of Fudan University

jiajie@eentanesthesia.com+86 189 1778 5693

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026