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To explore the mechanism of sgp130Fc in sepsis-induced acute kidney injury by regulating ferroptosis pathway based on IL-6/STAT3/TRIM21 axis

To explore the mechanism of sgp130Fc in sepsis-induced acute kidney injury by regulating ferroptosis pathway based on IL-6/STAT3/TRIM21 axis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500106821
Enrollment
Unknown
Registered
2025-07-30
Start date
2025-11-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Sepsis patients:NA

Sponsors

The Second Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients with sepsis admitted to our department, aged from 18 to 80 years old, conforming to sepsis3.0. 2. The approval was obtained from the ethics committee of the hospital, and all patients or legally authorized representatives signed informed consent.

Exclusion criteria

Exclusion criteria: 1. pregnant women; 2. patients with malignant tumors; 3. serious heart, liver, kidney dysfunction and other serious or even life-threatening diseases; 4. other conditions considered by other investigators to be unsuitable for inclusion.

Design outcomes

Primary

MeasureTime frame
IL-6;—

Countries

China

Contacts

Public ContactLiu Xuefang

The Second Hospital of Hebei Medical University

28604110@hebmu.edu.cn+86 159 3168 6132

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026