Metabolic and Cardiovascular disease
Conditions
Interventions
Group Receiving Normoxia Intervention Followed by Hypoxia Intervention:The intervention consisted of normoxia first, followed by hypoxia. The washout period is two days.
Group Receiving Hypoxia Intervention Followed by Normoxia Intervention:The intervention consisted of hypoxia first, followed by normoxia. The washout period is two days.
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. BMI >= 25 kg/m^2 2. No other metabolic diseases(e.g., diabetes, hypertension, etc.) 3. Age 18–50 years 4. No recent history of surgery, trauma, or major illness 5. No long-term use of medications that affect energy metabolism, such as hormonal agents, weight-loss drugs, or hypoglycemic medications 6. No travel to higher altitudes (>500 m) within the past three months.
Exclusion criteria
Exclusion criteria: 1. Physical limitations(e.g., musculoskeletal injuries, osteoarticular diseases, or pain) 2. Known cardiovascular, cerebrovascular, hepatic, renal, or other serious diseases 3. Exercise-related dyspnea 4. Family history of sudden unexpected death 5. Known coronary artery disease 6. Untreated endocrine disorders 7. Blood pressure >= 160/100 mmHg 8. Use within the past year of medications that affect metabolism or cardiovascular function 9. Current smoking or weekly alcohol intake >140 g (men) or >70 g (women) 10. Inability to adhere to the intervention protocol during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Energy metabolism;Carbohydrate and fat oxidation;Glucose;Endocrine hormones; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Respiratory quotient;Gastrointestinal hormones;Appetite ; | — |
Countries
China
Contacts
Public ContactGuang Ning
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed