Dup15q syndrome
Conditions
Interventions
Group younger:Oral All-Trans Retinoic Acid (ATRA)
Group elder:Oral All-Trans Retinoic Acid (ATRA)
Sponsors
The Second Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
3 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1.Clinical Diagnosis ??Conducted by two experienced physicians?? based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V); 2.Diagnostic Scale Assessment ??Performed by professionally certified examiners?? using ??ADOS-2; 3.Genetic Testing ??Diagnostic criteria via genomic analysis??: detection of 15q11-13 duplication?? containing UBE3A;
Exclusion criteria
Exclusion criteria: 1.?History of acute or chronic infection within the past 3 months?; 2.Active epileptic seizures within the past 6 months?; 3.Intake of nutritional supplements (e.g., vitamin A and/or minerals) within the past 1 month?; 4.History of chronic diseases, including abnormal liver function, abnormal renal function, or thyroid dysfunction?;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ADOS-2 Score; | — |
Countries
China
Contacts
Public ContactFeng Jianhua
The Second Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed