Laryngeal Mask Airway(LMA) insertion under General anesthesia
Conditions
Interventions
Oliceridine-Ciprofol Combination Group(O Group):Administer oliceridine 0.02 mg/kg intravenously, followed by ciprofol
Sponsors
Nanshan District People's Hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged 18-65 years, with normal cognitive function, scheduled for elective surgery under general anesthesia using a laryngeal mask airway. (2) Patients with normal liver and kidney function, classified as ASA physical status I or II. (3) Patients with a BMI of 18.5–30 kg/m². (4) Patients with a QTc interval <0.43 s. (5) Patients who voluntarily participate in the study and provide written informed consent. (6) Patients with no history of allergy to anesthetic drugs.
Exclusion criteria
Exclusion criteria: (1) Patients with significant organ dysfunction: severe hepatic or renal insufficiency; organic diseases of the heart, brain, or lungs; cardiac function >= NYHA Class III; coagulopathy; sick sinus syndrome; bradycardia (HR <55 bpm); or second-degree or higher atrioventricular block. (2) Patients with psychiatric disorders such as depression or mania. (3) Patients with chronic use of opioid or benzodiazepine medications. (4) Patients deemed unsuitable for inclusion by the investigator for any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the ED50 of ciprofol required for smooth LMA insertion in the two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| any perioperative adverse events; | — |
Countries
China
Contacts
Public ContactDu Jiamin
Nanshan District People's Hospital of Shenzhen
Outcome results
None listed