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The median effective dose of propofol for inhibiting body movement response in patients with anxiety or depression undergoing artificial abortion when combined with esketamine

The median effective dose of propofol for inhibiting body movement response in patients with anxiety or depression undergoing artificial abortion when combined with esketamine

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106772
Enrollment
Unknown
Registered
2025-07-30
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety or depression

Interventions

Anxiety or depression group:Esketamine 0.3mg/kg+ cyclopofol
Non-anxiety or depression group:Esketamine 0.3mg/kg+ cyclopofol

Sponsors

The Eighth Affiliated Hospital of Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Those who voluntarily choose painless abortion surgery and sign the informed consent form; 2. Intrauterine pregnancy 50 points.

Exclusion criteria

Exclusion criteria: 1. Suspected or definite history of long-term anesthetic drugs or sedative and analgesic drugs; 2. Those with a history of severe liver and kidney insufficiency or cardiovascular and cerebrovascular diseases such as hypertension and diabetes; 3. Those who have mental or neurological diseases that affect cognitive function and poor cooperation with doctors; 4. Those who are allergic to anesthetic drugs such as esketamine and cyclopofol; 5. Definite or potentially difficult airway or recent history of upper respiratory tract infection.

Design outcomes

Primary

MeasureTime frame
When combined with ketamine, cyclopofol is the half effective dose for inhibiting body movement response in patients with anxiety or depression undergoing induced abortion;

Countries

China

Contacts

Public ContactZhang Yiwen

The Eighth Affiliated Hospital of Southern Medical University

ssss047@163.com+86 137 9464 7543

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026