The impact of PEEP on cerebral blood flow in patients after non-cranial surgery: An observational and physiological study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500106767

Enrollment

Unknown

Registered

2025-07-30

Start date

2025-08-01

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral blood flow in patients after non-cranial surgery

Interventions

Case series:none

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Aged >=18 years, transferred to ICU after non-cranial surgery (such as thoracic and abdominal surgery, orthopedic surgery, etc.); (2) Mechanical ventilation with an expected ventilation duration of >=6 hours; (3) Agree and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Skull defect or poor penetration of TCD acoustic window; (2) Severe circulatory failure (norepinephrine dose >= 0.3 µg/kg/min); (3) Intracranial hemorrhage, cerebral infarction; (4) Abdominal compartment syndrome; (5) Oxygenation index less than 150mmHg; (6) Pregnancy; (7) Pneumothorax, mediastinal emphysema, pulmonary bulla; (8) Failure to sign the informed consent form.

Design outcomes

Primary

Measure	Time frame
PSV of middle cerebral artery;PI of middle cerebral artery;RI of middle cerebral artery;	—

Secondary

Measure	Time frame
blood gas analysis;blood pressure;	—

Countries

China

Contacts

Public ContactTang Yuan

Xinjiang Medical University Fifth Affiliated Hospital

626117021@qq.com+86 137 8701 5243

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026