Osteoporosis and Type 2 diabetes
Conditions
Interventions
Deslumab group:Subcutaneous injection of deslumab 60mg every six months
Zoledronic acid group:Intravenous infusion of zoledronic acid 5mg per year
Sponsors
The First People’s Hospital of Longquanyi District Chengdu, China
Eligibility
Sex/Gender
Female
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Postmenopausal women, aged 50-70 years; 2. Type 2 diabetes mellitus; 3. It meets the diagnostic criteria for osteoporosis in the guidelines for the diagnosis and treatment of primary osteoporosis, that is, it meets at least one of the following three criteria: (1) The T value of the bone mineral density of the axial bone (lumbar spine 1-4, femoral neck or total hip) or 1/3 of the distal radius measured by DXA is <= -2.5, (2) Fragile fractures of the hip or vertebral body, (3) The bone mineral density is -2.5<T value<-1.0, combined with brittle fractures of the proximal humerus, pelvis, or distal forearm; 4. Previous diagnosis or new diagnosis of osteoporosis, but no anti-osteoporosis treatment; 5. Did not take glucocorticoid treatment within half a year; 6. The patient was conscious and had no mental illness.
Exclusion criteria
Exclusion criteria: 1. Combined with other diseases that seriously affect bone metabolism, such as hyperparathyroidism or hypoparathyroidism, hyperthyroidism or hypothyroidism; 2. Patients with severe heart, liver, and lung dysfunction; 3. Renal function impairment (estimated glomerular filtration rate <= 60 ml/min/1.73m^2); 4. Hypercalcemia or hypocalcemia; 5. Allergic to the study drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral density;Beta-CrossLaps (ß-CTx);Blood electrolytes;Renal function ;24-hour urine electrolytes;Pain score ;Short Physical Performance Battery (SPPB) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Markers of bone metabolism; | — |
Countries
China
Contacts
Public ContactYing Jixiang
The First People’s Hospital of Longquanyi District Chengdu, China
Outcome results
None listed