Minimally conscious state
Conditions
Interventions
BurstDR waveform stimulation:After receiving electrical spinal cord stimulation, the surgical stimulator was programmed to adjust with BurstDR waveform stimulation and its programming parameters were
Tonic waveform stimulation:After receiving electrical spinal cord stimulation, the surgical stimulator was programmed to adjust with Tonic waveform stimulation and its programming parameters were reco
Sponsors
Nanjing Brain Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients 1. Sudden impairment of consciousness. 2. Those who have been in a state of impaired consciousness for more than 3 months and have not improved or deteriorated consciousness for more than 4 consciousness. 3. Trauma patients who have not improved or worsened their consciousness for more than 8 weeks after surgery. 4. Meets MCS diagnosis: Clinical assessment using the Coma Recovery Scale (Revised) (CRS-R), and the patient meets at least one of the items in the staring or visual tracking and pain localization assessments, with a repetition rate of >50%; Neuroelectrophysiological assessment - standard electroencephalogram (EEG) status graded as Type B or Tape C. Surgery 1. Patients who have undergone SCS short-course stimulation without response and have completed SCS phase II surgery in other hospitals or Nanjing Brain Hospital. 2. CT review after surgery without serious complications such as bleeding and infection.
Exclusion criteria
Exclusion criteria: 1. Concurrent neurodegenerative disease or life-threatening disease. 2. Epilepsy that is difficult to control with medication. 3. Patients who are exacerbated by systemic disease or are not expected to survive for a long time. 4. Spinal fracture or significant spinal stenosis. 5. Brain injury is missing more than 30%. 6. Patients who are undergoing other drug or device trials and have not completed follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale Revised Score;Electroencephalogramnalys index (supplemented by NVX EEG peak frequency system assessment); | — |
Secondary
| Measure | Time frame |
|---|---|
| functional near-infrared spectroscopy index;Positron Emission Computed Tomography index; | — |
Countries
China
Contacts
Public ContactZhang Wenbin
Nanjing Brain Hospital
Outcome results
None listed