Rheumatoid arthritis with muscle loss - osteoporosis
Conditions
Interventions
Treatment group:Administer 10mg qw of methotrexate+70mg qw of alendronate sodium vitamin D+traditional Chinese medicine compound for treatment
Control group:Administer 10mg qw of methotrexate+70mg qw of alendronate sodium vitamin D
Sponsors
Dongguan Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Diagnosis criteria of traditional Chinese medicine syndrome type: refer to the "2019 Guidelines for the Diagnosis and Treatment of Osteoporosis with Integrated Traditional Chinese and Western Medicine" and "2020 Guidelines for the Diagnosis and Treatment of Traditional Chinese Medicine for Rheumatoid Arthritis" The syndrome type is in line with the spleen and kidney yang deficiency and blood stasis type Main symptoms: joint tingling, cold pain in the waist and knees, loose stools after little appetite, and weakness in the limbs Secondary symptoms: fear of cold and warmth, abdominal distension, and yellowing of the complexion. Tongue image, pulse: tongue dark red, ecchymosis, thin white or white thick, greasy; The pulse is deep or thin. Western medicine diagnostic standards are based on: Diagnostic criteria for rheumatoid arthritis: Meets the 1987 American College of Rheumatology (ACR) or 2010 European League Against Rheumatism (EULAR) classification criteria for RA Diagnostic criteria for osteoporosis: Referring to the recommended diagnostic criteria for osteoporosis in Chinese, bone loss is diagnosed if BMD in one or more parts is 1.0 standard deviations below the normal peak bone of the same sex, and OP is diagnosed if it is 2.5 standard deviations below the normal peak of the same sex. Sarcopenia: Chinese expert consensus: the square ratio of skeletal muscle mass (kg) to height (m) of the limbs, i.e., SMI is lower than the average skeletal muscle mass of young adults of the same race by 2 standard deviations or BIA method is less than 7kg/m^2 for men and 5.7kg/m^2 for women; Inclusion Criteria: 1. Meet the above diagnostic criteria of traditional Chinese and Western medicine; 2. Age 20-80 years old; 3. Good compliance, able to receive treatment and various tests according to the norms.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women and mentally ill patients; 2. Patients with other rheumatic diseases; 3. Other secondary osteoporosis; 4. Combined with severe malnutrition, or with severe damage to the heart, brain, kidney, and hematopoietic system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone density;Traditional Chinese Medicine Syndrome Scoring;Limb skeletal muscle mass; | — |
Countries
China
Contacts
Public ContactPeng Jianhong
Dongguan Traditional Chinese Medicine Hospital
Outcome results
None listed