Postoperative delirium
Conditions
Interventions
Neostigmine group:Neostigmine 0.04 mg/kg + atropine 0.02 mg/kg should be administered for neuromuscular blockade reversal when monitoring shows TOFr > 0.5 and PSI > 60.
Sugammadex Group:Administer Sugammadex Sodium 2 mg/kg + 0.9% normal saline for neuromuscular reversal when monitoring shows TOFr > 0.5 and PSI > 60.
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: Consecutively selected elderly patients aged 65-80 (regardless of gender) scheduled to undergo elective total hip/knee arthroplasty under general anesthesia at our center between September 2025 and August 2026.
Exclusion criteria
Exclusion criteria: 1. Inability to provide informed consent or communication difficulties before surgery, with MMSE score 2.0 times the upper limit of normal) diseases; 3. Allergy to any of the anesthetic drugs to be used in the study; 4. History of mental illness or long-term use of psychiatric medications; 5. Contraindications to neostigmine or sugammadex sodium; 6. Patients who refuse to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient status index;Electromyography indicators;Four strings of stimuli;Electroencephalogram indicators;CAM Scale Score;Serological indicator; | — |
Secondary
| Measure | Time frame |
|---|---|
| Skeletal muscle content;Postoperative complications; | — |
Countries
China
Contacts
Public ContactZhaochu Sun
The First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed