Facial Aging?
Conditions
Interventions
Test group:Stem cell exosomes
Sponsors
Shenzhen Qianhai Shekou Free Trade Zone Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Subject can read documents and voluntarily signs informed consent form. 2. Age 18~60 years old (inclusive), either gender. 3. The subject presents with static facial wrinkles, and according to the facial wrinkle assessment scale, any single wrinkle (glabellar lines, forehead lines, crow's feet, infraorbital wrinkles, nasolabial folds, and/or marionette lines) scores >=4 points.
Exclusion criteria
Exclusion criteria: 1. Muscular or nervous system diseases diagnosed clearly in the past, such as facial muscular atrophy, facial paralysis, etc.. 2. Patients who have undergone facial rejuvenation procedures? including but not limited to IPL, fractional laser treatment, mesotherapy, microneedling, and chemical peels within 3 months prior to enrollment?, or botulinum toxin injections, microfocused ultrasound, radiofrequency devices, or radiofrequency microneedling ?within 6 months prior to enrollment?. 3. Pregnant or lactating women, or male/female subjects planning pregnancy? (self or partner) ?within 6 months?. 4. Subjects with conditions significantly affecting efficacy evaluation? (e.g., conspicuous scars, hypertrichosis); 5. Suffering from systemic diseases, being on medication, or have been diagnosed with tumors. 6. Have dysfunction or failure of important organs. 7. Patients with a history of severe mental illness. 8. Patients with poor treatment compliance. 9. Have coagulation dysfunction or abnormal hematopoietic system. 10. Hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) positive, and HBV-DNA in peripheral blood is higher than the detection limit; Hepatitis C virus (HCV) antibody positive; Human immunodeficiency virus (HIV) antibody positive; Syphilis test antibody positive. 11. Patients deemed by the investigator to be ineligible for participation in this clinical study for any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Investigator subjective evaluation;Safety evaluation;Changes of skin physiological indexes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subject satisfaction; | — |
Countries
China
Contacts
Public ContactHu Gang
Shenzhen Qianhai Shekou Free Trade Zone Hospital
Outcome results
None listed