Ischemic cardiomyopathy or dilated cardiomyopathy
Conditions
Sponsors
Nanping First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. diagnosed as ischemic cardiomyopathy or dilated cardiomyopathy (diagnostic criteria reference: (1) ischemic cardiomyopathy: heart failure that meets at least one of the following conditions: 1) previous history of myocardial infarction or revascularization; 2) Stenosis of the left main trunk or proximal anterior descending branch >= 75%; 3) Double or triple coronary artery stenosis>= 75%. (2) Dilated cardiomyopathy: objective evidence of ventricular enlargement and decreased myocardial systolic function: 1) left ventricular end diastolic diameter (LVEDd)>5.0 cm (female) and lvedd>5.5 cm (male) or greater than 117% of the predicted value of age and body surface area, i.e. 2 times SD+5% of the predicted value; (2) Lvef450 ng/L ;50–75 years: NT-proBNP >900 ng/L; >75 years: NT-proBNP >1800 ng/L; In renal insufficiency (eGFR 1200 ng/L ; 4.Age >=18 years. 5.New York Heart Association (NYHA) functional class III or IV: Class I: No limitation of physical activity. Ordinary activity does not cause undue fatigue, palpitations, dyspnea, or angina. Class II: Slight limitation of physical activity. Comfortable at rest, but ordinary activity results in fatigue, palpitations, dyspnea, or angina. Class III: Marked limitation of physical activity. Comfortable at rest, but less-than-ordinary activity causes fatigue, palpitations, dyspnea, or angina. Class IV: Symptoms occur at rest and worsen with any physical activity.
Exclusion criteria
Exclusion criteria: 1.Expected hospitalization time 2.5 times ULN; 5.Pregnant, breastfeeding, or planning to conceive within 3 months; 6.Individuals who are known or suspected to be allergic to the test product or its components; 7.Participate in other researchers within the past month; 8.Any other situation that researchers believe may put patients at risk.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NTproBNP; | — |
Secondary
| Measure | Time frame |
|---|---|
| 24-hour urine output;Galectin-3;Echocardiography related indicators: left ventricular ejection fraction, longitudinal strain, circumferential strain, global radial strain, left ventricular global systolic peak torsion angle, etc;Length of stay;Cardiac function classification;Growth differentiation factor 15(GDF-15);Soluble tumor suppressor protein-2 (sst2);Weight;Use rate of inotropic drugs and intravenous vasodilators (excluding study drugs);Symptom improvement; | — |
Countries
China
Contacts
Public ContactYanqing Wu
Nanping First Hospital
Outcome results
None listed