Effect of Paracetamol and Mannitol Injection on Perioperative Intracranial Pressure in Bariatric Surgery Patients: A Single-Center, Prospective, Interventional Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500106686

Enrollment

Unknown

Registered

2025-07-28

Start date

2025-04-11

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intracranial Pressure

Interventions

Control Group :Routine anesthesia

Experimental Group (Paracetamol and Mannitol Injection Group):The acetaminophen mannitol group (acetaminophen mannitol injection, 500 mg/50ml) was instillated intravenously after intubation under gene

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Patients scheduled for elective bariatric surgery under general anesthesia; 2.Age between 18 and 60 years old; 3.American Society of Anesthesiologists (ASA) I~III.

Exclusion criteria

Exclusion criteria: 1.Allergy to nonsteroidal anti-inflammatory drugs; 2.Pre-existing ocular diseases or prior ocular surgery; 3.Presence of intracranial pathology; 4.Patients with severe cardiac, pulmonary, hepatic, or renal dysfunction.

Design outcomes

Primary

Measure	Time frame
Optic nerve sheath diameter;	—

Secondary

Measure	Time frame
Postoperative complications (such as pain, headache, dizziness, nausea/vomiting, and blurred vision);	—

Countries

China

Contacts

Public ContactXiaoping Gu, Zhang Wei

Drum Tower Hospital Affiliated to Nanjing University School of Medicine

xiaopinggu@nju.edu.cn+86 25 83106666

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026