Effects of remazolam on cerebral oxygen saturation and postoperative cognitive function in elderly patients undergoing laparoscopic radical surgery for colorectal cancer

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500106681

Enrollment

Unknown

Registered

2025-07-28

Start date

2023-03-09

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer

Interventions

Rimazolam group:Group R was induced with remazolam (0.3-1 mg/kg) combined with sufentanil (0.3 µg/kg) with cis-atracurium (0.15 mg/kg)

Propofol group:In group P, propofol (2-4 mg/kg) combined with sufentanil (0.3 µg/kg) with cis-atracurium (0.15 mg/kg) was used for induction

Eligibility

Sex/Gender

All

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) age 60 to 75 years; (2) American Society of Anesthesiologists (ASA) classification II to III; (3) body mass index (BMI) 18 to 27 kg/m²; (4) hemoglobin (Hb) >100 g/L.

Exclusion criteria

Exclusion criteria: (1) Simple Mental State Evaluation Scale (MMSE) score = grade 2; (9) fasting blood glucose >=11.1 mmol/L.

Design outcomes

Primary

Measure	Time frame
cerebral oxygen saturation;	—

Secondary

Measure	Time frame
Brief Mental State Examination Scale (MMSE);	—

Countries

China

Contacts

Public ContactLu Jing

Linyi People's Hospital

17661666379@163.com+86 135 6291 4301

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026