Oral Squamous Cell Carcinoma
Conditions
Interventions
Healthy Control Group:None
Oral Potentially Malignant Disorders Group:None
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Grouping: 1. Healthy control group (1) Age>=18 years old, gender is not limited; (2) No history of oral mucosal disease and head and neck tumor; (3) No abnormal symptoms such as oral ulcers and inflammation in the past 3 months; (4) No history of systemic autoimmune diseases, hematological diseases and other malignant tumors; (5) Not taking immunosuppressants or anticoagulant drugs for a long time; 2. Oral potential malignant lesion group Clinical examination and pathological biopsy confirmed as: (1) Oral leukoplakia (OLK) II/III. grade; (2) Oral erythema (Erythroplakia); (3) oral lichen planus (OLP) with epithelial dysplasia; (4) oral submucosal fibrosis (OSF); (5) Lesion duration>=3 months; (6) No treatment for local or systemic precancerous lesions 3. Oral cancer group (1) Pathologically confirmed as squamous cell carcinoma (OSCC) without surgery, radiotherapy or chemotherapy; (2) TNM stage I-IVA; (3) Treatment-naïve patients (who have not received anti-tumor therapy). 2. Compliance: The subject is willing and able to complete the collection and follow-up of saliva and blood samples according to the requirements of the study, and the subject or his family has signed the informed consent form 3. Others: One hour before sample collection, no eating, drinking, chewing gum, smoking, rinsing or engaging in any activities that may bring substances into the mouth.
Exclusion criteria
Exclusion criteria: 1. Other diseases or comorbidities: have autoimmune diseases; History of other systemic malignancies; History of chemoradiotherapy, surgery, or alternative drug therapy; Severe cardiovascular and cerebrovascular disease (NYHA class III-IV); Long-term use of antiplatelet/anticoagulant drugs (> 3 months); Major surgery or trauma within 6 months; Combined with severe mental illness and unable to cooperate with sampling; Combined with HIV/AIDS, active hepatitis and other infectious diseases; 2. Special population: pregnant or lactating women. 3. Others: Oral diagnosis and treatment within 48 hours before sample collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk of oral cancer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor stage;Survival time; | — |
Countries
China
Contacts
Public ContactLiao Lan
The first affiliated hostipal of nanchang university
Outcome results
None listed