None
Conditions
Interventions
Tegretolide group:The first patient was initiated with induction of anesthesia by intravenous tegiridine 1 mg, followed by 1-2 mg/kg propofol. When the patients electroencephalogram bifrequency index
If the previous patient had a negative reaction to laryngeal mask placement, the dose was determined by BCD-UDM randomization: a computer was used to generate a random number with a range of 1~95, and
When the random number is 1~5, the next patient has a gradient drop in tagliridine dose, that is, there is an 11% (b=0.11) probability of decreasing by one gradient (0.1mg) and an 89% (1-b=0.89) proba
Sponsors
The First People’s Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 65 and 80 years old; 2.ASA physical status I-III; 3.BMI between 18 and 30 kg/m^2 (including boundary values); 4.Mallampati grade I or II, mouth opening >2.5 cm; 5.No airway, head and neck condition abnormalities; 6.No risk of regurgitation and aspiration (such as in cases of full stomach, obesity, gastrointestinal obstruction, etc.); 7.Estimated operative time <180 minutes; 8.Scheduled for urological surgery requiring general anesthesia and laryngeal mask airway insertion; 9.Subjects voluntarily participate in this study and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Baseline measurements: severe hypertension (systolic blood pressure over 160 mmHg or diastolic blood pressure over 100 mmHg), heart rate below 60 beats per minute or above 100 beats per minute; 2.Long-term use of alcohol, sedatives, and analgesics, or allergy to any drugs used in the study; 3.Significant organ dysfunction in heart, lung, liver, kidney, nervous system, neuromuscular diseases, hyperthyroidism, obstructive sleep apnea syndrome; 4.History of mental illness or severe cognitive impairment that prevents understanding of study content and cooperation; 5.Administration of sedative-hypnotic drugs (including benzodiazepines and barbiturates) before surgery; 6.Upper respiratory tract infection within 1 month before surgery; 7.Participation in other clinical trials within the last 3 months; 8.Other reasons deemed unsuitable for participation in the trial by the researcher;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether a reaction to laryngeal mask placement occurs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of successful cases of laryngeal mask placement;Number of adverse reactions;Blood pressure;Adverse Reaction Rate;Heart rate;Pulse Oxygen Saturation;Bispectral Index; | — |
Countries
China
Contacts
Public ContactZhao Zhibin
The First People’s Hospital of Lianyungang
Outcome results
None listed