NasopharyngealCarcinoma
Conditions
Interventions
control group:Routine oral care: The control group received routine oral care from the first day of radiotherapy until the end of radiotherapy, for a total of 7 weeks.
intervention group:Based on the routine oral care plan, the evidence-based oral care plan constructed in the first stage was implemented for a total of 7 weeks.
Sponsors
People's Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with nasopharyngeal carcinoma by imaging and histopathological examination and receiving simultaneous chemoradiotherapy for the first time; 2. Patient >=18 years old, clear consciousness and active cooperation; 3. KPS score >=70; 4. Sign informed consent and participate in the study voluntarily.
Exclusion criteria
Exclusion criteria: (1) Patients with distant metastasis of the lesion, combined with other malignant tumors or severe diseases in other organs, or mental disorders; (2) Those with a history of primary or chronic oral ulcers, periodontitis and other oral diseases; (3) Those who have used antibiotics, steroids and other hormones (including oral, intramuscular or intravenous injection) or taken probiotics (yogurt, live bacteria capsules) and other microecological preparations within one month before sample collection; (4) Those who are unable to cooperate for various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral flora Alpha diversity;Chao1 index /ACE index;PD-whole tree index;SOBS Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| The PH value of oral saliva;Resting salivary flow rate;Incidence of oral mucositis and severity of oral mucositis;The incidence rate and severity of xerostomia; | — |
Countries
China
Contacts
Public ContactFu Guifen
People's Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed