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Significance of FGF21 and klotho in rhGH treatment of ISS

Significance of FGF21 and klotho in rhGH treatment of ISS

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106663
Enrollment
Unknown
Registered
2025-07-28
Start date
2025-08-11
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Short stature

Interventions

Experimental group :The experimental group received growth hormone therapy
Control group:The control group did not receive intervention

Sponsors

China People's Liberation Army Central Theater General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 9 Years

Inclusion criteria

Inclusion criteria: Meets the diagnostic criteria for idiopathic short stature in children (1. Height below 2 standard deviations (-2SD) of the average height of children of the same age, gender, and race; 2. Normal birth length and weight, with no history of rescue suffocation; 3. When the GH peak value of the growth hormone complex stimulation test is greater than 10ng/ml, GHD is excluded; 4. Normal or slightly delayed growth rate and bone age; 5. Exclude children with various diseases known to cause dwarfism, aged between 3-9 years old.

Exclusion criteria

Exclusion criteria: Infants who are younger than gestational age, have other serious endocrine disorders, cardiovascular diseases, genetic diseases, chromosomal diseases, or other diseases that affect growth and development.

Design outcomes

Primary

MeasureTime frame
Fasting detection of FGF21;Klotho ;

Secondary

MeasureTime frame
blood sugar;insulinum;Triglyceride (TG);Free fatty acid (FFA);Lipoprotein a (Lp-a);

Countries

China

Contacts

Public ContactMinShu Zou

China People's Liberation Army Central Theater General Hospital

zoum19710801@163.com+86 153 8717 0025

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026