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Comparison of the brain protective effects of different sedatives on pediatric patients undergoing upper limb surgeries with ERAS mode

Comparison of the brain protective effects of different sedatives on pediatric patients undergoing upper limb surgeries with ERAS mode

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106639
Enrollment
Unknown
Registered
2025-07-28
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital upper limb deformity

Interventions

Propofol group :Group propofol: After entering the operating room, the patient will be intravenously injected with 1% lidocaine 1mg/kg to prevent injection pain. Then, 2.5mg/kg propofol will be given
Dexmedetomidine group :Group dexmedetomidine: After entering the operating room, 0.2µg/(kg·min) dexmedetomidine is intravenously pumped for 10 minutes (i.e. a total amount of 2µg/kg), and then continu

Sponsors

Department of Anesthesiology, Beijing Jishuitan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
4 Years to 7 Years

Inclusion criteria

Inclusion criteria: 1.Age 4-7 years old; 2.Intend to undergo unilateral upper limb surgery.

Exclusion criteria

Exclusion criteria: 1. Developmental delay; 2. Severe malnutrition; 3. Brain injury; 4. Cerebral palsy; 5. Severe developmental abnormalities of the heart or other organs; 6. Allergic to anesthesia related drugs; 7. Children who still resist to venipuncture under consolation and skin surface anesthesia at the puncture site; 8. The expected surgery time is longer than 2 hours.

Design outcomes

Primary

MeasureTime frame
Incidence of delirium during the recovery period;

Secondary

MeasureTime frame
Serum level of brain injury markers;

Countries

China

Contacts

Public ContactYuanfang Zheng

Beijing Jishuitan Hospital

zhengyuanfang_214@hotmail.com+86 185 1822 0908

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026