Slow transit constipation
Conditions
Interventions
Dual-target magnetic stimulation group:Repetitive transcranial magnetic stimulation and sacral nerve magnetic stimulation
single stimulus group:Pseudo-repetitive transcranial magnetic stimulation and sacral nerve magnetic stimulation
Sponsors
Chengdu Anorectal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Meets the Rome IV diagnostic criteria for chronic functional constipation, with a disease duration of at least 6 months; (2) Age: over 18 years old; (3) Can be clearly diagnosed with generalised anxiety disorder or major depressive disorder according to DSM-5 criteria; (4) Positive colon transit test; (5) Patient informed consent and voluntary participation in the study.
Exclusion criteria
Exclusion criteria: (1) Exclude central nervous system disorders such as Parkinson's disease, stroke, traumatic brain injury, cerebral palsy, multiple sclerosis, and peripheral nerve disorders such as diabetic peripheral neuropathy and metabolic peripheral neuropathy; (2) Exclude constipation caused by organic colonic lesions, such as colonic tumours, megacolon, and colonic diverticula; (3) History of major abdominal or perineal surgery, such as colostomy (excluding minor surgeries like appendectomy or haemorrhoidectomy), and coexisting other types of intestinal diseases like intestinal obstruction or inflammatory bowel disease; (4) Uncontrolled hypertension; (5) Pregnancy or lactation period; (6) Individuals with infections in the sacral 2-4 region and the corresponding DLPFC region of the head; (7) Individuals with a pacemaker or other metallic devices; (8) Patients with cognitive impairments who cannot cooperate; (9) Alcohol abuse; (10) Individuals unable to undergo electrode placement due to anatomical limitations; (11) Individuals currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Colon transit test;High-resolution anorectal manometry; | — |
Secondary
| Measure | Time frame |
|---|---|
| Constipation Severity Instrument;DASS-21;Genital nerve motor evoked potential;SF-36 QoL; | — |
Countries
China
Contacts
Public ContactChunmei Luo
Chengdu Anorectal Hospital
Outcome results
None listed