Advanced Gastrointestinal Malignancies with Liver Metastases
Conditions
Interventions
Cohort1: gastric cancer group:microwave hyperthermia
Cohort2: colorectal cancer group:microwave hyperthermia
Sponsors
The First Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 75 years, male or female; 2. Histologically or cytologically confirmed diagnosis of gastrointestinal malignancy with liver metastases; 3. Prior treatment requirements: - Gastric cancer patients must have received at least one prior line of systemic therapy. - Colorectal cancer patients must have received at least two prior lines of systemic therapy. 4. Clinically assessed as suitable for hyperthermia combined with immune checkpoint inhibitor therapy; 5. At least one measurable lesion meeting RECIST 1.1 criteria; 6. Expected survival >=6 months; 7. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1; 8. Adequate organ and bone marrow function; 9. Willingness to provide sufficient baseline and post-treatment samples, ability to comply with long-term follow-up and evaluation, and signed informed consent. 10. No prior history of other malignancies;
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Any comorbidities or underlying medical conditions that, in the investigator's judgment, render the patient unsuitable for study participation; 3. Presence of other severe physical or psychiatric disorders, or clinically significant laboratory abnormalities that may increase the risk associated with study participation, interfere with study results interpretation, or otherwise make the patient inappropriate for inclusion as determined by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression Free Survival;Disease Control Rate;Overall Survival; | — |
Countries
China
Contacts
Public ContactXiujuan Qu
The First Hospital of China Medical University
Outcome results
None listed