Chronic Postsurgical Pain
Conditions
Interventions
Group C:From the beginning of anesthesia induction until 30 minutes before the end of the surgery, an equivalent amount of saline solution was injected as in Group E. No esketamine was included in the
Group E:Esketamine was administered from anesthesia induction until 30 minutes before the end of surgery. It was also added to the postoperative analgesia pump for supplemental pain control.
Sponsors
Tongling People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA physical status I–II; 2. Aged 18–65 years; 3. BMI: 18–30 kg/m²; 4. Effective communication skills and the capacity to comprehend and independently complete all study scales; 5. Patients with lower extremity fractures involving the distal fem,.ur region (including femoral shaft, patella, tibiofibular and calcaneal fractures) requiring tourniquet use during surgical intervention
Exclusion criteria
Exclusion criteria: 1. Patients with severe organic diseases or chronic pain disorders (e.g., rheumatoid arthritis, rheumatic arthritis); 2. Prior surgical procedures involving lower extremity fracture fixation; 3. Chronic preoperative use of analgesic agents (opioids, NSAIDs, or other pain medications); 4. Any contraindication to esketamine administration including severe hypertension, glaucoma; 5. Patients with severe psychiatric disorders; 6. Excluding metatarsal/phalangeal fractures and external fixation cases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chronic postsurgical pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain catastrophizing scores;Acute postsurgical pain;Tourniquet reaction;Hospital Anxiety and Depression Scale;plasma IL-6 and CRP;Pain rescue medication; | — |
Countries
China
Contacts
Public ContactTang Ting
Tongling People's Hospital
Outcome results
None listed