Migraine
Conditions
Interventions
Control group:sham stimulation treatment
FNS treatment group:FNS group
control group(health group):None
Sponsors
Second people's hospital of Chengdu
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age 18-50 years old; According to the third edition of Headache Classification and Diagnostic Criteria (ICDH-3) published by the International Headache Society, the diagnostic requirements for chronic migraine are: >=15 days/month of headache, lasting at least 3 months, of which at least 8 days per month of headache meet the diagnostic criteria for migraine or migraine specific drugs are effective.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Patients with special types of migraine, such as ophthalmoplegic migraine, hemiplegic migraine, etc. Have received preventive migraine treatment in the past 3 months; Have used at least 3 preventive medications; Patients with secondary headache; Those undergoing hormone therapy; Some characteristic groups such as pregnant women, nursing patients, drug users, etc.; Serious organic or mental illness; MRI contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compared with baseline, change in headache days at month 3; ;50% response rate, that is, a reduction of >=50% in headache days at month 3 compared to baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| fMRI;BOLD-fMRI;Compared with baseline, Change in mean monthly headache days during the 3-month treatment period;Changes in headache frequency during the 3rd month;Changes in the frequency of any headaches during the third month;Change in headache severity at month 3;The proportion of analgesics used and the frequency of taking analgesics in the third month;MIDAS score change;Patient satisfaction with treatment at the end of the third month of the trial;FNSVitamin D levels;Leukocyte count;Neutrophil count;C-reactive protein;HAMD;HAMA;The HAMD changed after FNS treatment;Differences in functional magnetic resonance imaging between the normal group and the chronic migraine group;The HAMA changed after FNS treatment; | — |
Countries
China
Contacts
Public ContactLanying He
Second people's hospital of Chengdu
Outcome results
None listed