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Using streptodornase before a gastroscopy—does it make the view clearer and find more problems?

Clinical Study on Streptokinase Protease in Improving Endoscopic Visual Field and Lesion Detection Rate Under Gastroscopy

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106615
Enrollment
Unknown
Registered
2025-07-28
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Small lesions in the stomach, precancerous lesions and early gastric cancer

Interventions

Experimental group:Oral administration of pronase and dimethicone before gastroscopy
Control group:Oral dimethicone before gastroscopy

Sponsors

Haiyan People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 74 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing routine painless gastroscopy; 2. Age 18-74 years old, gender is not limited; 3. Volunteer to participate in this study and sign the informed consent form; 4. No contraindications to gastroscopy.

Exclusion criteria

Exclusion criteria: 1.Severe dysfunction of heart, liver, kidney or other organs, or coagulation abnormalities; 2.those with subtotal gastrectomy, gastrointestinal obstruction, severe esophagogastric varices or definite gastric malignant tumors; 3.pregnant or lactating women; 4.those allergic to pronase, dimethicone or excipients; 5.those with mental illness or unable to cooperate; 6.and other individuals who do not meet the inclusion criteria as judged by researchers.

Design outcomes

Primary

MeasureTime frame
Detection rate of tiny lesions;Detection rate of precancerous lesions;Detection rate of early gastric cancer;Clarity of the endoscopic examination field of view;

Secondary

MeasureTime frame
Total time of gastroscopy;Incidence rate of adverse reactions;

Countries

China

Contacts

Public ContactCai Chunhua

Haiyan People's Hospital

13616732571@139.com+86 136 1673 2571

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026