Generalized anxiety disorder
Conditions
Interventions
Active rTMS stimulation group:1.Instruments: The rTMS device (Shenzhen YINGCHI Technology Co., Ltd.) with 8-shaped coil is adopted, and the 8-shaped coil is employed. 2.Stimulation parameters: The sti
3.Stimulation target: the stimulation location is set on the right dorsolateral prefrontal cortex (DLPFC) based on the 10-20 electroencephalogram (EEG) positioning system, and the coil must be tangent
(2) They also need to remove metal glasses, watches, hearing AIDS, etc. During the treatment period, patients should be required to maintain the same posture to avoid off-target stimulation.
Sham rTMS stimulation group:The treatment will be administered using rTMS device with the 8-shaped sham coil (Shenzhen YINGCHI Technology Co., Ltd.). The coil will not be electrified, and will generat
Sponsors
Sichuan Province Bayi Rehabilitation Center (Sichuan Province Rehabilitation Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 65 years with no gender restrictions. 2.Right-handedness (Edinburgh Handedness Inventory score > 40); 3.Meeting the diagnostic criteria for GAD according to the fifth edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-V); 4.Hamilton Anxiety Scale (HAMA) scores >=14 points, and Hamilton Depression Rating Scale-24 (HAMD-24) scores < 7 points; 5.No prior use of anxiolytic medications before enrollment, or discontinuation of anxiolytic medications for at least two weeks; 6.No history of drug or alcohol abuse; 7.Voluntarily participate in the research and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Diagnosis of depression; 2.Suffering from endocrine system disorders (e.g., diabetes mellitus, thyroid diseases); 3.Presence of neurological disorders (e.g., Parkinson's disease, dementia); 4.Combined with other psychiatric disorders (e.g., bipolar disorder, obsessive-compulsive disorder, schizophrenia) 5.Having suicidal ideation or behavior; 6.Pregnancy or lactation; 7.Suffering from severe cardiac disease; 8.With hearing impairments; 9.Having a history of epilepsy; 10.Presence of intracranial or metallic implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale, HAMA Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Generalized anxiety disorder-7, GAD-7 Score;Pittsburgh Sleep Quality Index, PSQI;Social Disability Screening Schedule, SDSS Score;Hamilton Depression Scale, HAMD-24 Score; | — |
Countries
China
Contacts
Public ContactJuan Li
Sichuan Province Bayi Rehabilitation Center (Sichuan Province Rehabilitation Hospital)
Outcome results
None listed