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Exploring the value of monitoring effluent ionized calcium in continuous renal replacement therapy with regional citrate anticoagulation - a noninferiority randomized controlled study

The value of monitoring effluent ionized calcium in continuous renal replacement therapy with regional citrate anticoagulation

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500106613
Enrollment
Unknown
Registered
2025-07-28
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney injury

Interventions

Test group:A point-of-care blood gas analyzer (RADIOMETER ABL90 FLEX) test was used to determine the level of effluent ionized calcium, in order to adjust the citrate dosage for anticoagulation.
Control group:A point-of-care blood gas analyzer (RADIOMETER ? ABL90 FLEX) test was routinely used to detect the level of post-filted blood ionized calcium, in order to adjust the citrate dosage for a

Sponsors

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >= 18 years old. 2. Patients who are hospitalized at Run Run Shaw Hospital, School of Medicine, Zhejiang University and diagnosed with acute kidney injury requiring RCA-CRRT treatment. 3. Voluntarily participates in this study and sign an informed consent form. If the subject is unable to read and sign the informed consent form due to reasons such as lack of legal capacity, or if the subject is a juvenile, their guardian must act as a proxy for the informed process and sign the informed consent form. If the subject lacks the ability to read the informed consent form (such as illiterate subjects), a witness must witness the informed process and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients under the age of 18. 2. Patients who refuse to sign informed consent forms and do not agree to participate in this study.

Design outcomes

Primary

MeasureTime frame
Filter survival;Blood gas analysis;ICU survival;

Secondary

MeasureTime frame
CRRT supporting time;Blood collection volume during RCA-RRT process;Reasons for filter failure;

Countries

China

Contacts

Public ContactJianping Gao

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

gaojp@zju.edu.cn+86 137 7740 0742

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026