Mantle cell lymphoma
Conditions
Interventions
Experimental group:ZSDT(Zuberitamab+Selinexor+Dexamethasone+Thalidomide)
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1: 1.Ages 18-70, ECOG score 0-2(including ages 18 and 70) 2: 2.Overall Survival > 6 months 3: 3.The diagnosis of mantle cell lymphoma was confirmed by histopathology. 4.At least one measurable lesion 4: 5.Acceptable hematologic parameters, no contraindications to chemotherapy, absolute neutrophil >= 1.0 × 10 ^ 9 L, platelet >= 75 × 10 ^ 9 L, hemoglobin >= 80 g/L (except for patients with bone marrow infiltration) , 6.Liver function: direct bilirubin <= 1.5 × upper limit , Alanine transaminase or aspartate transaminase <= 2.5 × upper limit , Alkaline phosphatase<= 3 × ULN in patients without non-bone involvement, 7.Renal function: serum creatinine <= 1.5 ×ULN 5: 8.Women of Childbearing Potential (WOBCP) or men and their WOBCP partners should agree to take effective contraceptive measures from the signing of ICF and WOBCP must undergo a serum pregnancy test within seven days before the first medication and the results are negative. 9.Recurrent refractory patients after BTK inhibitor treatment, 10. The subjects voluntarily partici;
Exclusion criteria
Exclusion criteria: 1.Refusing to take blood samples 2: 2. Previous allergies to any of the medications in the regimen 3: 3. Pregnant and lactating women 4. The researchers believe that major diseases can cause interference in the trial. 5. Combined with other tumors. 6. There are drug-related contraindications to treatment in the protocol 4: 7. People with severe mental illness 5: 8. Participating in other clinical trials 6: 9. Any severe or uncontrolled systematic disease, such as: uncontrolled diabetes 7: severe heart failure (NYHA Class II or higher) 8: acute coronary syndrome in the last 6 months 9: Coronary revascularization, such as stent implantation, coronary artery bypass grafting, and other heart and large vessel related procedures performed within the last 6 months 10: severe arrhythmias include frequent premature ventricular contractions, ventricular tachycardia, rapid atrial fibrillation atrial flutter, and severe bradycardia. Uncontrolled hypertension: systolic pressure > 180 mmHg and/or diastolic pressure >100 mmHg;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete response rate, CRR; | — |
Countries
China
Contacts
Public ContactXudong Zhang
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed