Hypertension
Conditions
Interventions
Self-control group:Drug intervention
Intervention group:Spironolactone 40mg
Control group:None
Sponsors
Guizhou Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age: 30-75 years old; (2) Before drug treatment, the systolic blood pressure in the office was in the range of 160-190mmHg and/or the diastolic blood pressure was in the range of 100-120mmHg; (3) The family/office with more than 4 weeks of drug treatment and ambulate blood pressure is not up to the standard and within the above range (exceeding the target systolic/diastolic blood pressure 160pg/ml; (5) Blood potassium < 4.8mmol/L; (6)Sign written informed consent, accept random assignment, and expect good compliance.
Exclusion criteria
Exclusion criteria: 1) Age, consulting room blood pressure and ambulate blood pressure did not meet the inclusion criteria; 2) Secondary hypertension with definite diagnosis, including primary hyperaldosteronism, Cushing's syndrome, pheochromocytoma, renal artery stenosis, renin tumor, cocotation of the aorta, etc. 3) History of ischemic or hemorrhagic stroke within 3 months (excluding lacunar infarction and TIA). 4) hospitalization within 3 months due to myocardial infarction or unstable angina, or coronary revascularization (PCI or CABG). 5) History of aortic dissection/dissection aneurysm rupture. 6) Exacerbation of chronic heart failure during hospitalization for NYHAIII-IV heart failure within 3 months or upon admission. 7) A history of persistent atrial fibrillation, atrial flutter, or other severe arrhythmias upon admission (including bradysinus, diseased sinus, high atrioventricular block, frequent ventricular premature, etc.). 8) Severe liver disease or liver dysfunction: AST, ALT, or ALP > 5ULN (5 times the upper limit of normal), or BIL > 3ULN (3 times the upper limit of normal). 9) End-stage renal disease receiving dialysis or eGFR2.5mg/dL[>221µmol/L]). 10) Patients with serious physical diseases such as malignant tumors and autoimmune diseases. 11) Severe cognitive or mental impairment. 12) Pregnant and lactating women. 13) Participate in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure; | — |
Countries
China
Contacts
Public ContactSongFang
Guizhou Provincial People's Hospital
Outcome results
None listed