Depression
Conditions
Interventions
Esketamine group:Intravenous bolus injection of 0.5 mg/kg esketamine
Control group:Intravenous bolus injection of an equal volume of normal saline
Sponsors
The Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients aged over 18 years. 2.American Society of Anesthesiologists (ASA) physical status classification I to II. 3.Patients with osteoarthritis scheduled for joint replacement surgery. 4.Patients with a score greater than 8 on the 17-item Hamilton Depression Rating Scale (HAMD-17).
Exclusion criteria
Exclusion criteria: 1.The patient has comorbidities such as hypertension, coronary heart disease, or cerebral infarction. 2.The patient has a history of psychiatric disorders other than depression, such as schizophrenia or Alzheimer's disease. 3.The patient has recently received treatment with ketamine or esketamine. 4.The patient is unable to cooperate with the administration of the Hamilton Depression Rating Scale (HAMD-17). 5.The patient refuses to undergo treatment with esketamine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale (HAMD) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;IL-1ß;TNF-a;Length of hospital stay;Mortality rate;Surgical complications; | — |
Countries
China
Contacts
Public ContactMao Li
The Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed