Schizophrenia
Conditions
Interventions
TIs Group [4Hz]- IPL target group :Temporal Interference Stimulation (TIS) targeted IPL brain area
tACS Group [4Hz] - IPL target group :Transcranial Alternating Current Stimulation (tACS) targeted IPL brain area
TIs Sham Stimulation Group:Temporal Interference Stimulation-Sham, TI-Sham
tACS Sham Stimulation Group:Transcranial Alternating Current Stimulation-Sham, tACS-Sham
TIs Group [4Hz]- DLPFC target group :Temporal Interference Stimulation (TIS) targeted DLPFC brain area
Sponsors
Beijing Huilongguan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of DSM-5 schizophrenia; 2. Age 18-45 years old; 3. Years of education> = 6 years; 4. First onset, total disease course <=5 years; 5. Obvious working memory deficits: spatial breadth test <=5 points in the cognitive function kit (defined according to the mean of the Chinese norm -95% confidence interval); 6. The total cycle of previous systematic use of antipsychotics, antidepressants, emotional stabilizers and other psychotropic drugs <=2 weeks; 7. Right-handed; Normal vision and hearing (or corrected), no color blindness or color blindness, no communication disorders; 8. The patient's legal guardian and/or patient voluntarily participated in the study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Accompanied by mental retardation or other brain organic diseases, with an IQ of less than 85 points; 2. Severe recession or impulsive excitement and uncooperation; 3. Accompanied by severe depression, anxiety, and substance abuse (except tobacco); 4. Organic auditory or/visual perception impairment; 5. Non-unstable state, severe physical diseases or serious drug side effects (such as severe extrapyramidal reactions, tardive dyskinesia, etc.); 6. Pregnant or lactating women; 7. Taking immunomodulators, neurotrophics, antioxidants, etc. in the past 8 weeks; 8. Infectious diseases occurred in the past 2 weeks; 9. Received physical modulation therapy such as tDCS, tACS, TMS and non-convulsive electroconvulsive therapy in the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Schizophrenia Symptom Severity - Clinician-Rated Scale;Working Memory Task Behavioral Performance Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of cognitive impairment;EEG activity; | — |
Countries
China
Contacts
Public ContactDeng Hu
Beijing HuiLongGuan Hospital
Outcome results
None listed