Schizophrenia
Conditions
Interventions
paliperidone:paliperidone palmitate injection
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Outpatient or inpatient patients with schizophrenia who meet the DSM-5 diagnostic criteria; (2) Age range for screening is 18 to 65 years old (including threshold values), with no gender restrictions; (3) At the time of enrollment, the patient had received at least 4 injections of risperidone microspheres (II) for treatment, and the PANSS scale included 8 symptoms: P1 delusions, P2 conceptual disorder, and P3 hallucinations Behavior, N1 emotional dullness, N4 social avoidance, N6 lack of spontaneity and fluency in language communication, G5 appearance and posture, G9 rating for unusual thinking content All scores are <= 3 points; (4) The subject or their guardian signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1) The patient has been diagnosed with other mental illnesses besides schizophrenia; (2) Individuals with serious physical illnesses, mental retardation, organic brain disorders, and mental disorders caused by physical illnesses; (3) Men with QTc interval>450ms and women with QTc interval>460ms; (4) History of abuse of psychoactive substances (excluding tobacco) in the past 12 months, with obvious suicidal tendencies or violent behavior; (5) Individuals who have had or currently have delayed onset motor disorders (TD), antipsychotic malignant syndrome (NMS), or severe extrapyramidal adverse reactions; (6) Patients with refractory schizophrenia, who have currently or previously used two or more antipsychotic drugs of different compounds that are ineffective after sufficient treatment The person; (7) Individuals who have previously been allergic to risperidone or paliperidone or have had ineffective treatment; (8) Pregnant or lactating women or those planning to conceive, or those who cannot guarantee effective contraception during the study period; (9) Researchers believe that patients are not suitable for other situations in clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rating of Medication Satisfaction Questionnaire (MSQ); | — |
Countries
China
Contacts
Public ContactDengtang Liu
Shanghai Mental Health Center
Outcome results
None listed